The Callisto Protocol has 43 Collectible Locations (23 Implant Bios, 20 Data-Bios Audio Logs). Finding all of the Bios Collectibles unlocks the Grim Reaper Trophy and Achievement.
Everything is missable! There is no Chapter Select and no New Game Plus. You must find all Collectibles in one playthrough. The game keeps multiple autosaves going back a few checkpoints, if you missed one and notice right away you can reload the closest autosave and replay from there. You can also keep Manual Saves, which is highly recommended. Keep at least one Manual Save from the start of each Chapter. The chosen difficulty setting doesn’t matter for Collectibles. There are no Side Quests or hidden requirements, they can all be found on the first playthrough.
Dying resets your progress to what you had at the last Checkpoint. If you die, you must recollect anything since the last checkpoint!
Note that the official Grim Reaper trophy/achievement description is misleading. It states to “harvest and read all implant bios”. However, you also need the regular Audio Logs, not just the harvested implant bios. They all count as “Data-Bios” in the game. They are all included here in the guide. Implant Bios are harvested from corpses whereas Audio Logs are found as collectible pickups in the environment. Both types are mandatory for the Grim Reaper trophy, so be sure to get all of them and not just the Implants. The Grim Reaper trophy pops after the 42nd Data-Bio Collectible, which is a regular Audio Log and not a harvested Implant Bio. It actually pops one collectible early, the 43rd collectible isn’t needed for some reason.
You can keep track which ones you found by pressing 
> 
/ 
> Data-Bios Menu. In this menu there’s a sidebar on the left that lists them by Chapter. There you can see all available ones per Chapter. Each Audio Log & Harvested Implant is listed under the person they belong to. Some of the persons have multiple Bios across different Chapters, but the Data-Bios Menu shows the total amount across the entire game. For example, Dr. Caitlyn Mahler would show “1/4” collected after Chapter 2, this is normal because the remaining 3 Bios of this person are found in later Chapters.
By following this guide you will also get all other Trophies & Achievements for Platinum/1000 Gamerscore in 1 Playthrough.
Potential Bug Warning: Sometimes a Collectible might not register correctly in the Data-Bios Menu, then it remains blacked out in the menu. If this happens reload the last Autosave and collect it again! If one remains blacked out in the Data-Bios Menu, the trophy won’t unlock! It’s recommended to check at the start of every Chapter that all entries from the previous chapter are filled in (none are blacked out). If something didn’t register, reload the nearest save and recollect everything from that point onward. That’s also why you should keep plenty of Manual Saves.
Patch 5.02 (June 29, 2023) changed 11 Data Bio Locations!
All Data-Bios & Implant Bios by Chapter:
Below are links to all Collectibles by Chapter, there are 8 Chapters total:
- Chapter 1: Cargo – 1 Collectible
- Chapter 2: Outbreak – 3 Collectibles
- Chapter 3: Aftermath – 8 Collectibles
- Chapter 4: Habitat – 7 Collectibles
- Chapter 5: Lost – 8 Collectibles
- Chapter 6: Below – 5 Collectibles
- Chapter 7: Colony – 7 Collectibles
- Chapter 8: Tower – 4 Collectibles
That’s all 8 Chapters and their Collectibles in The Callisto Protocol.
Is the attached video accurate for people playing the latest fully updated version of this game ? November 2023.
That bug warning is only half right. I collected two that failed to register along the way without realizing it and still got the achievement when I picked up the last one despite those two still being blacked out.
Do you remember which ones they were? I’m in the last chapter, and I have 2 still blacked out. I’m 100% sure I picked up one of them, but the other one maybe I forgot to grab it again after I died, though I’m not sure. It’s driving me crazy with anxiety!