His Vile Sanctum is the 14th main mission in Borderlands 4 (BL4). This walkthrough will guide you through all objectives of the His Vile Sanctum Main Quest.
- Starting Location: Kairos > Terminus Range > Windspear
- Quest Giver: Defiant Calder
- Unlock Requirement: having completed Main Quest 13: Dark Subject
- Recommended Level: 18
- Reward: XP, Money, Eridium, Rare Sniper, Armed Collection Vault Hunter Head & Carapacer Vehicle
- Quest Description: Vile Lictor’s heinous plans are set in motion. It’s time to break into his fortress and take him down… with or without the help of the Auger Claves.
Objectives:
- Reach Vile Lictor’s fortress & Follow Amara
- Kill Orbulus
- Return to Belton’s Bore
- Follow Defiant Calder
- Reach power substation
- Find energy spike & Kill Order forces
- Find energy spike & Kill Order forces
- Find energy spike & Find Defiant Calder
- Find energy spike & Kill Order forces with Bruce
- Find energy spike & Follow Bruce
- Destabilize Phase device & Escort Bruce to limiter A
- Destabilize Phase device & Destroy limiter A
- Destabilize Phase device & Escort Bruce to limiter B
- Destabilize Phase device & Destroy limiter B
- Destabilize Phase device & Escort Bruce to limiter C
- Destabilize Phase device & Destroy limiter C
- Breach Vile Lictor’s fortress & Huddle near Bruce
- Breach Vile Lictor’s fortress & Enter Phase rift
- Breach Vile Lictor’s fortress & Enter Phase rift
- Breach Vile Lictor’s fortress & Enter Phase rift
- Breach Vile Lictor’s fortress
- Breach Vile Lictor’s fortress & Find Bruce
- Breach Vile Lictor’s fortress & Find engineering bay
- Breach Vile Lictor’s fortress & Insert Bruce’s control core
- Breach Vile Lictor’s fortress & Destroy barrier
- Breach Vile Lictor’s fortress & Use Bruce Bombs to destroy barriers
- Kill Vile Lictor & Destroy Phase barrier
- Kill Vile Lictor & Destroy Eridian relics
- Kill Vile Lictor & Kill Vile twins
- Kill Vile Lictor & Continue with Amara
- Kill Vile Lictor & Activate elevator
- Kill Vile Lictor + Optional Objective: Check on Amara
- Take Vile Lictor’s bolt
- Return to Calder
Starting Location: His Vile Sanctum
Reach Vile Lictor’s fortress & Follow Amara
Follow Amara upstairs.
Then head over the bridge to the other side.
Kill Orbulus
On the other side, you will find Orbulus, you need to kill him.
Return to Belton’s Bore
After killing Orbulus, you can fast travel back to Belton’s Bore.
Follow Defiant Calder
Now follow Calder until he stops.
Reach power substation
Follow the quest marker to the substation.
Find energy spike & Kill Order forces
Inside the substation, kill all enemies to proceed.
Find energy spike & Kill Order forces
After that, head into the next area where you kill some more enemies.
Find energy spike & Find Defiant Calder
Follow the marker to a wall nearby to find Calder.
Find energy spike & Kill Order forces with Bruce
Bruce will break through the wall. This objective will end instantly.
Find energy spike & Follow Bruce
Now follow Bruce into a room with a big purple energy spike. On the way, kill enemies when they attack Bruce, or he won’t move forward.
Destabilize Phase device & Escort Bruce to limiter A
Bruce will head to the right side first, and make sure to kill enemies or he does not move forward.
Destabilize Phase device & Destroy limiter A
Bruce will destroy the shield around the limiter, which you now have to shoot to destroy it.
Destabilize Phase device & Escort Bruce to limiter B
Now follow Bruce to the exact opposite of the room to find limiter B.
Destabilize Phase device & Destroy limiter B
Shoot the limiter to destroy it.
Destabilize Phase device & Escort Bruce to limiter C
Now follow Bruce to the north side of the room to find the last limiter.
Destabilize Phase device & Destroy limiter C
Destroy the last limiter after Bruce destroyed the shield.
Breach Vile Lictor’s fortress & Huddle near Bruce
Just wait near Bruce to finish this objective. You will automatically get teleported soon after.
Breach Vile Lictor’s fortress & Enter Phase rift
Just follow the path, you can run past enemies and enter the rift.
Breach Vile Lictor’s fortress & Enter Phase rift
In the next area repeat the process, just move forward and enter the rift at the end to teleport to the next area.
Breach Vile Lictor’s fortress & Enter Phase rift
Do the same as above one more time, and just run forward and enter the rift.
Breach Vile Lictor’s fortress
Now head to the open area in front of you.
Breach Vile Lictor’s fortress & Find Bruce
Here you will find Bruce’s body in the north-east part of the area, you can’t miss him.
Breach Vile Lictor’s fortress & Find engineering bay
From Bruce, turn right and enter the building on the left side, and follow the path until you reach a control room.
Breach Vile Lictor’s fortress & Insert Bruce’s control core
Interact with the table to insert Bruce’s core.
Breach Vile Lictor’s fortress & Destroy barrier
Pick up the yellow orb with 
/ 
and throw it onto the barrier behind you.
Breach Vile Lictor’s fortress & Use Bruce Bombs to destroy barriers
Then head back outside, and you will already notice two purple bubbles.
To the right of the right bubble, you will find another one of Bruce’s projectiles. Pick it up and throw it onto the bubble, then shoot the core inside to destroy it.
Then pick up another projectile and throw it onto the second bubble, and repeat the process.
Kill Vile Lictor & Destroy Phase barrier
Go through the now-open door and follow the path. You will reach another barrier. Destroy it with a projectile located on your right side.
Follow the path more, and you will reach another barrier soon.
To reach the projectile to destroy the barrier, go around the area into the north-west corner and you will see a vent that you can open.
In the room you reach, open the door to your right first, then pick up the projectile and throw it onto the barrier.
Enter the elevator behind the barrier and interact with it.
Kill Vile Lictor & Destroy Eridian relics
You will reach a room with a total of three relics.
Turn left as soon as you enter and jump over to the projectile, then throw the projectile onto the relic on the right side. Then shoot the relic to destroy it.
Repeat the process for the relic on the left side.
Now, from the projectile, head to the opposite side of the room to find the last relic. The projectile to destroy the barrier is to the right of the relic, you can not use the first projectile for this.
Kill Vile Lictor & Kill Vile twins
Now head to the middle of the room where the twins will spawn. Kill them.
Kill Vile Lictor & Continue with Amara
Simply follow Amara after killing the twins.
Kill Vile Lictor & Activate elevator
After killing some enemies, you will reach another elevator. Use it.
Kill Vile Lictor + Optional Objective: Check on Amara
After the elevator ride, a cutscene will start, and after that cutscene, before taking the jump pad, turn right to check on Amara to complete the optional objective.
Then use the jumpad to reach Vile Lictor.
In the first phase (when he still has his yellow bar), you can only damage him when his mouth is open.
In the second phase (when the blue bar is gone), you can damage him anywhere. But his crit spot is still his mouth.
Take Vile Lictor’s bolt
After killing him, pick up his bolt.
Return to Calder
You can now fast travel back to Belton’s Bore to talk to Calder.
This finishes His Vile Sanctum in Borderlands 4.
NEXT: Rising Action
For all other Quests refer to our complete Borderlands 4 Walkthrough.
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